Article

<i>In silico</i> modelling human VPS13 proteins associated with donor and target membranes suggests lipid transfer mechanisms

2022-07-29

Abstract excerpt

The VPS13 protein family constitutes a novel class of bridge-like lipid transferases. Autosomal recessive inheritance of mutations in VPS13 genes is associated with the development of neurodegenerative diseases in humans. Bioinformatic approaches previously recognised the domain architecture of these proteins. In this study, we model the first ever full-length structures of the four human homologs VPS13A, VPS13B,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d99e6f76-207d-5b90-ae76-b334d2e13efd
DOI: 10.1101/2022.07.27.501698

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In silico</i> modelling human VPS13 proteins associated with donor and target membranes suggests lipid transfer mechanismsDOI 10.1101/2022.07.27.501698Read

In silico modeling human VPS13 proteins associated with donor and target membranes suggests lipid transfer mechanisms.Semantic proximity Read

Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport.Semantic proximity Read

In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contactsSemantic proximity Read

The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites.Semantic proximity Read

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read

Phosphatidylethanolamines are the main lipid class altered in red blood cells from patients with VPS13A disease/chorea-acanthocytosisSemantic proximity Read

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairSemantic proximity Read

Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease.Semantic proximity Read

Beyond Static Tethering at Membrane Contact Sites: Structural Dynamics and Functional Implications of VAP ProteinsSemantic proximity Read

Stairway to the Golgi: Two paths VPS13B can go by.Semantic proximity Read

A shared binding interface controls Vps13 organelle-specific targeting independently of its vacuolar protein sorting function.Semantic proximity Read