Article
The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.
The Journal of cell biology - 1 Feb 2017
De Mithu, Oleskie Austin N, Ayyash Mariam, Dutta Somnath, Mancour Liliya, Abazeed Mohamed E, Brace Eddy J, Skiniotis Georgios, Fuller Robert S
Abstract excerpt
Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine. Mutations in three of four human VPS13 genes cause autosomal recessive neurodegenerative or neurodevelopmental disease, making yeast Vps13p an important structural and functional model. Using cell-free reconstitution with purified Vps13p, we show that Vps13p is directly required both for transport from...
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