Article

Single-cell multi-omic velocity infers dynamic and decoupled gene regulation

2021-12-15

Abstract excerpt

Single-cell multi-omic datasets, in which multiple molecular modalities are profiled within the same cell, provide a unique opportunity to discover the relationships between cellular epigenomic and transcriptomic changes. To realize this potential, we developed MultiVelo, a mechanistic model of gene expression that extends the RNA velocity framework to incorporate epigenomic data. MultiVelo uses a probabilistic la...

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Identifiers and source

Literature Corpus work: 34cd06da-fc9a-593a-b21f-a955a6e665e1
DOI: 10.1101/2021.12.13.472472

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