Article

Enhancer buffering protects dosage-sensitive housekeeping genes during vulnerable developmental transitions

2026-07-30

Abstract excerpt

Housekeeping genes maintain robust expression across cell types despite dynamic transcription factor fluctuations, yet their haploinsufficiency is associated with many tissue-specific developmental disorders. To understand this paradox, we focus on TCOF1, a broadly expressed regulator of rRNA synthesis, whose haploinsufficiency causes Treacher Collins syndrome (TCS). We show that transitional cranial neural crest...

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Literature Corpus work: 2a1e5b1a-cade-5982-a7fb-f27852ec30a5
DOI: 10.64898/2026.07.29.741571

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