Article

Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition <i>in cell</i> and is negatively affected in the UBTF-E210K neuroregression syndrome

2021-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Transcription of the ∼200 mouse and human ribosomal RNA genes (rDNA) by RNA Polymerase I (RPI/PolR1) accounts for 80% of total cellular RNA, around 35% of all nuclear RNA synthesis, and determines the cytoplasmic ribosome complement. It is therefore a major factor controlling cell growth and its misfunction has been implicated in hypertrophic and developmental disorders. Activation of each rDNA...

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Literature Corpus work: 1c0db168-2516-5ecf-85aa-0e9f738f5d7d
DOI: 10.1101/2021.06.07.447350

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