Article

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development

2021-09-22

Abstract excerpt

Ribosomal RNA (rRNA) transcription by RNA Polymerase I (Pol I) is a critical rate-limiting step in ribosome biogenesis, which is essential for cell survival. Despite its global function, disruptions in ribosome biogenesis cause tissue-specific birth defects called ribosomopathies, which frequently affect craniofacial development. Here, we describe a cellular and molecular mechanism underlying the susceptibility of...

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Literature Corpus work: b0544264-ded9-5608-b6d2-21f08e017919
DOI: 10.1101/2021.09.22.461379

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