Article
TREM2 Alteration Increases AD Biomarkers and is Associated with Key Genes with 5xFAD Mice Model Analysis on MODEL-AD Database
2023-08-07
Abstract excerpt
Alzheimer Disease is a multifactorial disorder characterized by cognitive decline and memory loss. A key gene associated with AD is the TREM2 gene which has been identified as a risk factor for AD. Studies show that TREM2 functions in microglia regulation that controls the amount of AB proteins by the mechanisms of clearance and degradation. However, the exact mechanism of how the TREM2 variations like TREM2 KO an...
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Identifiers and source
- Literature Corpus work
- d2dcaf27-6f8d-55d2-b766-5b5921ccc06e
- DOI
- 10.1101/2023.08.06.552135