Article

Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: evidence for “polygenic epistasis”

2019-02-19

Abstract excerpt

<h4>Background</h4> The majority of quantitative genetic models used to map complex traits assume that alleles have similar effects across all individuals. Significant evidence suggests, however, that epistatic interactions modulate the impact of many alleles. Nevertheless, identifying epistatic interactions remains computationally and statistically challenging. In this work, we address some of these challenges b...

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Literature Corpus work: 2a16c63f-8688-5552-b2fa-ca2a5e3decdd
DOI: 10.1101/555383

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