Article
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.
Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2008
Shao Haifeng, Burrage Lindsay C, Sinasac David S, Hill Annie E, Ernest Sheila R, O'Brien William, Courtland Hayden-William, Jepsen Karl J, Kirby Andrew, Kulbokas E J, Daly Mark J, Broman Karl W, Lander Eric S, Nadeau Joseph H
Abstract excerpt
The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude of their effects, or the extent to which they interact. Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and...
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