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Article

Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis".

PLoS genetics - 1 Oct 2020

Rau Christoph D, Gonzales Natalia M, Bloom Joshua S, Park Danny, Ayroles Julien, Palmer Abraham A, Lusis Aldons J, Zaitlen Noah

Abstract excerpt

BACKGROUND: The majority of quantitative genetic models used to map complex traits assume that alleles have similar effects across all individuals. Significant evidence suggests, however, that epistatic interactions modulate the impact of many alleles. Nevertheless, identifying epistatic interactions remains computationally and statistically challenging. In this work, we address some of these challenges by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33104702
DOI: 10.1371/journal.pgen.1009165
PMCID: PMC7644088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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