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Article

Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits.

Nature communications - 30 Sept 2025

Miller Anna K, Bartlett Jacquelaine, Pan Calvin, Lusis Aldons J, Crawford Dana C, Williams Scott M, Buchner David A

Abstract excerpt

A better understanding of genetic architecture will help enhance precision medicine and clinical care. Towards this end, we investigate sex-stratified analyses for several traits in the Hybrid Mouse Diversity Panel (HMDP) and UK Biobank to assess trait polygenicity and identify contributing loci. By comparing allelic effect directions in males and females, we hypothesize that non-associated loci should show...

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Identifiers

PMID: 41028716
DOI: 10.1038/s41467-025-63763-x
PMCID: PMC12485208

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