Article

A synthetic protein as efficient multitarget regulator against complement over-activation

2021-04-27

Abstract excerpt

The complement system constitutes the innate defense against pathogens. Its dysregulation leads to diseases and is a critical determinant in many viral infections, e.g.COVID-19. Factor H (FH) is the main regulator of the alternative pathway of complement activation and could be a therapy to restore homeostasis. However, recombinant FH is not available. Engineered FH versions may present alternative therapeutics. H...

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Literature Corpus work: 29f37211-52f3-5935-9206-002addcf4855
DOI: 10.1101/2021.04.27.441647

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