Article
Factor H family proteins: on complement, microbes and human diseases.
Biochemical Society transactions - 1 Nov 2002
Zipfel P F, Skerka C, Hellwage J, Jokiranta S T, Meri S, Brade V, Kraiczy P, Noris M, Remuzzi G
Abstract excerpt
At present, the human Factor H protein family represents seven multidomain, multifunctional serum proteins. This group includes the complement and immune regulators Factor H, the Factor H-like protein 1 (FHL-1) and five Factor H-related proteins proteins (FHR-1, -2, -3, -4 and -5). Each is exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control...
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