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Article

Unraveling the Effect of a Potentiating Anti-Factor H Antibody on Atypical Hemolytic Uremic Syndrome-Associated Factor H Variants.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2020

Dekkers Gillian, Brouwer Mieke C, Jeremiasse Jorn, Kamp Angela, Biggs Robyn M, van Mierlo Gerard, Lauder Scott, Katti Suresh, Kuijpers Taco W, Rispens Theo, Jongerius Ilse

Abstract excerpt

The complement system plays an important role in our innate immune system. Complement activation results in clearance of pathogens, immune complex, and apoptotic cells. The host is protected from complement-mediated damage by several complement regulators. Factor H (FH) is the most important fluid-phase regulator of the alternative pathway of the complement system. Heterozygous mutations in FH are associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32848031
DOI: 10.4049/jimmunol.2000368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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