Article

Unravelling the effect of a potentiating anti-Factor H antibody on atypical hemolytic uremic syndrome associated factor H variants

2020-04-09

Abstract excerpt

The complement system plays an important role in our innate immune system. Complement activation results in clearance of pathogens, immune complex and apoptotic cells. The host is protected from complement-mediated damage by several complement regulators. Factor H (FH) is the most important fluid-phase regulator of the alternative pathway of the complement system. Heterozygous mutations in FH are associated with c...

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Literature Corpus work: bd39afc5-d868-50f7-a935-296760ea0c36
DOI: 10.1101/2020.04.08.026906

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