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Article

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.

Nature immunology - 1 Jul 2009

Wu Jin, Wu You-Qiang, Ricklin Daniel, Janssen Bert J C, Lambris John D, Gros Piet

Abstract excerpt

Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b. FH interacted with multiple domains of C3b, covering a large, extended surface area. The structure indicated that FH...

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Identifiers

PMID: 19503104
DOI: 10.1038/ni.1755
PMCID: PMC2713992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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