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Article

Structural Analysis of the C-Terminal Region (Modules 18–20) of Complement Regulator Factor H (FH)

28 Feb 2012

Abstract excerpt

Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on self-surfaces and accelerates the decay of the alternative pathway C3 convertase, C3bBb. We have determined the crystal structure of the three carboxyl-terminal...

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PMID: 22389686
DOI: 10.1371/journal.pone.0032187

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