Article

Presynaptic α <sub>2</sub> δ subunits are key organizers of glutamatergic synapses

2019-10-31

Abstract excerpt

In nerve cells the genes encoding for α 2 δ subunits of voltage-gated calcium channels (VGCCs) have been linked to synaptic functions and neurological disease. Here we show that α 2 δ subunits are essential for the formation and organization of glutamatergic synapses. Using a cellular α 2 δ subunit triple loss-of-function model, we demonstrate a failure in presynaptic differentiation associated with the downsca...

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Literature Corpus work: 29ede2e1-17f0-5012-9231-60cfdf58eb0f
DOI: 10.1101/826016

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