Article

α2δ-2 protein controls structure and function at the cerebellar climbing fiber synapse

2019-06-28

Abstract excerpt

α2δ proteins ( Cacna2d1-4 ) are auxiliary subunits of voltage-dependent calcium channels that also drive synapse formation and maturation. Because cerebellar Purkinje cells (PCs) only express one isoform of this family, α2δ-2 ( Cacna2d2 ), we used PCs as a model system to examine roles of α2δ in excitatory synaptic function in a Cacna2d2 knockout mouse. Whole-cell recordings of PCs from acute cerebellar slices...

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Literature Corpus work: ff9b53df-43d5-5c6c-b9c4-b44c8031ee3c
DOI: 10.1101/685818

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