Article
Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation.
Neuroscience letters - 10 May 2017
Oh Jun-Young, Rhee Sangmyung, Silva Alcino J, Lee Yong-Seok, Kim Hyong Kyu
Abstract excerpt
Glutamate is the major excitatory neurotransmitter in the central nervous system, and related signaling involves both AMPA and NMDA subtype receptors. The expression of glutamate receptors is dynamically regulated during development. Recent studies showed that the dysregulation of glutamate receptor expression and function is associated with neurodevelopmental disorders including intellectual disability....
Topics
- Animals
- Cells, Cultured
- Hippocampus
- Mutation
- Neurons
- Noonan Syndrome
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Rats
- Receptors, AMPA
- Receptors, N-Methyl-D-Aspartate