Article
α2δ-3 Is Required for Rapid Transsynaptic Homeostatic Signaling.
Cell reports - 13 Sept 2016
Wang Tingting, Jones Ryan T, Whippen Jenna M, Davis Graeme W
Abstract excerpt
The homeostatic modulation of neurotransmitter release, termed presynaptic homeostatic potentiation (PHP), is a fundamental type of neuromodulation, conserved from Drosophila to humans, that stabilizes information transfer at synaptic connections throughout the nervous system. Here, we demonstrate that α2δ-3, an auxiliary subunit of the presynaptic calcium channel, is required for PHP. The α2δ gene family has...
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