Article
α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly.
Cell reports - 20 Jul 2021
Li Lingyong, Chen Shao-Rui, Zhou Meng-Hua, Wang Li, Li De-Pei, Chen Hong, Lee Garam, Jayaraman Vasanthi, Pan Hui-Lin
Abstract excerpt
Many neurological disorders show an increased prevalence of GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs), which dramatically alters synaptic function. However, the molecular mechanism underlying this distinct synaptic plasticity remains enigmatic. Here, we show that nerve injury potentiates postsynaptic, but not presynaptic, CP-AMPARs in the spinal dorsal horn via α2δ-1. Overexpressing α2δ-1,...
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