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Article

Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.

Genes & development - 15 Oct 2007

Rohrbough Jeffrey, Rushton Emma, Woodruff Elvin, Fergestad Tim, Vigneswaran Krishanthan, Broadie Kendal

Abstract excerpt

Formation and regulation of excitatory glutamatergic synapses is essential for shaping neural circuits throughout development. In a Drosophila genetic screen for synaptogenesis mutants, we identified mind the gap (mtg), which encodes a secreted, extracellular N-glycosaminoglycan-binding protein. MTG is expressed neuronally and detected in the synaptic cleft, and is required to form the specialized transsynaptic...

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Identifiers

PMID: 17901219
DOI: 10.1101/gad.1574107
PMCID: PMC2000325

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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