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Article

Elevated <i>de novo</i> fatty acid biosynthesis gene expression promotes melanoma cell survival and drug resistance

2018-10-11

Abstract excerpt

Elevated de novo fatty acid biosynthesis (DNFA) is a hallmark adaptation in many cancers that supports survival, proliferation, and metastasis. Here we elucidate previously unexplored aspects of transcription regulation and clinical relevance of DNFA in melanomas. We show that elevated expression of DNFA genes is characteristic of many tumor types and correlates with poor prognosis. Elevated DNFA gene expression...

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Identifiers and source

Literature Corpus work
975d8495-79d4-59ce-8ae8-218b3dd71f7d
DOI
10.1101/441303
Open publication

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