Article

The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenance

2021-08-27

Abstract excerpt

B cells have been implicated as central regulators of immune responses in settings as diverse as mammalian pregnancy, mucosal tolerance, chronic infection states, autoimmunity, and the tumor microenvironment. Despite the established importance of B cells in these environments, the mechanisms by which B cells are maintained in these contexts remain undefined. Here, we report that IDO1 pathway inhibition with D-1-me...

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Literature Corpus work: ef5a31a8-06fb-5c86-bf0c-789c4c89b4fa
DOI: 10.1101/2021.08.25.456776

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