Article

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance

2024-04-27

Abstract excerpt

<h4>SUMMARY</h4> Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized clinical cancer treatment, while abnormal PD-L1 or HLA-I expression in patients can significantly impact the therapeutic efficacy. Somatic mutations in cancer cells that modulate these critical immune regulators are closely associated with tumor progression and ICB response. However, a systematic interpretation of cancer...

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Literature Corpus work: b1083079-0f23-583d-bfa4-ffa3f7d6d7cb
DOI: 10.1101/2024.04.25.591036

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