Article

Reconstructed Cell-Type Specific Rhythms in Human Brain link Alzheimer’s Pathology, Circadian Stress, and Ribosomal Disruption

2025-02-26

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) disrupts behavioral circadian rhythms, but its effects on molecular rhythms in the human brain are poorly understood. Using single-nucleus RNA sequencing from post-mortem cortical samples, we informatically estimated the relative circadian phases of 409 persons with and without AD dementia. We then reconstructed circadian expression profiles across cell types. While core...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2980dcfc-3304-551a-be3f-51813cb7175f
DOI: 10.1101/2025.02.21.639499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reconstructed Cell-Type Specific Rhythms in Human Brain link Alzheimer’s Pathology, Circadian Stress, and Ribosomal DisruptionDOI 10.1101/2025.02.21.639499Read

Human brain cell-type-specific aging clocks based on single-nuclei transcriptomicsSemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

Local clocks within human tissues reveal widespread 24-hour rhythms in gene expressionSemantic proximity Read

A novel bioinformatics approach to reveal the role of circadian oscillations in AD developmentSemantic proximity Read

A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or agingSemantic proximity Read

Combined analysis of single-cell and bulk RNA sequencing reveals the expression patterns of circadian rhythm disruption in the immune microenvironment of Alzheimer’s diseaseSemantic proximity Read

Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome functionSemantic proximity Read

Single-cell Transcriptomic Variance Analysis Reveals Intercellular Circadian Desynchrony in the Alzheimer’s Affected Human BrainSemantic proximity Read

Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity Read

HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s diseaseSemantic proximity Read

Multi-Transcriptomic Analysis Points to Early Organelle Dysfunction in Human Astrocytes in Alzheimer’s DiseaseSemantic proximity Read

Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer’s disease modelSemantic proximity Read