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Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function

30 Jan 2025

Abstract excerpt

The prevalence of Alzheimer's disease (AD) is increasing as society ages. The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. We performed an RNA sequencing analysis on a cohort of 1227 Japanese blood samples, representing 424 AD patients, 543 individuals with mild...

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PMID: 39885278
DOI: 10.1038/s41598-025-88526-y

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