Article

Single-cell Transcriptomic Variance Analysis Reveals Intercellular Circadian Desynchrony in the Alzheimer’s Affected Human Brain

2026-03-25

Abstract excerpt

Bulk tissue rhythms arise from the coordination of thousands of individual cellular oscillations. Bulk rhythm amplitude differences may reflect changes in the amplitude of the underlying cellular oscillators or changes in their temporal coherence. To resolve this fundamental ambiguity, we developed ORPHEUS ( O scillatory R hythm P hase H eterogeneity E stimated U sing S tatistical-moments), an analytical me...

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Literature Corpus work: 4af38447-918e-5217-926d-75fe3ab27338
DOI: 10.64898/2026.03.23.713759

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