Article

Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer’s disease model

2026-01-28

Abstract excerpt

Diurnal rhythms in brain transcription align neural, immune, and metabolic processes with the light–dark cycle and are profoundly disrupted in Alzheimer’s disease (AD). However, the regional organization of diurnal transcription in the healthy and diseased brain remains poorly defined. Using large-scale spatial transcriptomics, we mapped 24-hour rhythmic transcription across cortical and subcortical regions of the...

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Identifiers and source

Literature Corpus work: 22731c11-67da-580f-b514-bb23c843adaf
DOI: 10.64898/2026.01.26.701799

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