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Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing

3 Feb 2023

Abstract excerpt

To uncover the role of satellite cells (SCs) in paravertebral muscle development and aging, we constructed a single-nucleus transcriptomic atlas of mouse paravertebral muscle across seven timepoints spanning the embryo (day 16.5) to old (month 24) stages. Eight cell types, including SCs, fast muscle cells, and slow muscle cells, were identified. An energy metabolism-related gene set, TCA CYCLE IN SENESCENCE, was...

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PMID: 37554180
DOI: 10.1016/j.gendis.2023.01.005

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