Article

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

2025-02-03

Abstract excerpt

Tendons are mostly avascular dense connective tissues that link muscles to bones, withstanding some of the highest mechanical stresses in the body. Mechanical overload and tissue hypervascularity are implicated in tendinopathy, a common musculoskeletal disorder, but mechanistic understanding of their roles is largely lacking. Here, we identify HIF1α not only as a marker but as a driver of tendinopathy. Initial his...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a22c53f6-dbe1-5aa0-89c3-421f624b1925
DOI: 10.1101/2025.02.02.635939

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitmentDOI 10.1101/2025.02.02.635939Read

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathySemantic proximity Read

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomicsSemantic proximity Read

Widespread diversity in the transcriptomes of functionally divergent limb tendonsSemantic proximity Read

Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signalingSemantic proximity Read

Overexpression of mechanical sensitive miR-337-3p alleviates ectopic ossification in rat tendinopathy model via targeting IRS1 and Nox4 of tendon-derived stem cellsSemantic proximity Read

Towards an Understanding of the Genetics of Tendinopathy.Semantic proximity Read

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendonSemantic proximity Read

New Insights into Neuromuscular Contracture Reveals Myotendinous-SMAD4 Signaling Underlies Contracture FormationSemantic proximity Read

Targeting the NF-κB signaling pathway in chronic tendon diseaseSemantic proximity Read

The role of stromal-immune cell interactions in the pathogenesis of tendinopathySemantic proximity Read

Regulation of gene expression in human tendinopathy.Semantic proximity Read

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcificationSemantic proximity Read