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Article

Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta.

eLife - 26 May 2021

Grol Matthew William, Haelterman Nele A, Lim Joohyun, Munivez Elda M, Archer Marilyn, Hudson David M, Tufa Sara F, Keene Douglas R, Lei Kevin, Park Dongsu, Kuzawa Cole D, Ambrose Catherine G, Eyre David R, Lee Brendan H

Abstract excerpt

Osteogenesis imperfecta (OI) is characterized by short stature, skeletal deformities, low bone mass, and motor deficits. A subset of OI patients also present with joint hypermobility; however, the role of tendon dysfunction in OI pathogenesis is largely unknown. Using the Crtap-/- mouse model of severe, recessive OI, we found that mutant Achilles and patellar tendons were thinner and weaker with increased...

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Identifiers

PMID: 34036937
DOI: 10.7554/eLife.63488
PMCID: PMC8186905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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