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Article

Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing.

Nature communications - 11 May 2023

Selvam Kathiresan, Sivapragasam Smitha, Poon Gregory M K, Wyrick John J

Abstract excerpt

Sequencing of melanomas has identified hundreds of recurrent mutations in both coding and non-coding DNA. These include a number of well-characterized oncogenic driver mutations, such as coding mutations in the BRAF and NRAS oncogenes, and non-coding mutations in the promoter of telomerase reverse transcriptase (TERT). However, the molecular etiology and significance of most of these mutations is unknown. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37169747
DOI: 10.1038/s41467-023-38265-3
PMCID: PMC10175485

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