Article

Extensive germline-somatic interplay drives prostate cancer through HNF1B co-option of TMPRSS2-ERG

2021-09-03

Abstract excerpt

Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and clinical impact remain to be investigated. Here we observe an enrichment of transcription factor genes including HNF1B within PCa risk-associated regions. While focused on the 17q12/HNF1B locus, we find a strong eQTL for HNF1B and multiple potential causal variants involved in the regu...

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Literature Corpus work: 2964cda5-90d9-5a83-9ff6-cbd655e3d520
DOI: 10.1101/2021.09.02.458755

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