Article
The long tail of oncogenic drivers in prostate cancer.
Nature genetics - 1 May 2018
Armenia Joshua, Wankowicz Stephanie A M, Liu David, Gao Jianjiong, Kundra Ritika, Reznik Ed, Chatila Walid K, Chakravarty Debyani, Han G Celine, Coleman Ilsa, Montgomery Bruce, Pritchard Colin, Morrissey Colm, Barbieri Christopher E, Beltran Himisha, Sboner Andrea, Zafeiriou Zafeiris, Miranda Susana, Bielski Craig M, Penson Alexander V, Tolonen Charlotte, Huang Franklin W, Robinson Dan, Wu Yi Mi, Lonigro Robert, Garraway Levi A, Demichelis Francesca, Kantoff Philip W, Taplin Mary-Ellen, Abida Wassim, Taylor Barry S, Scher Howard I, Nelson Peter S, de Bono Johann S, Rubin Mark A, Sawyers Charles L, Chinnaiyan Arul M, Schultz Nikolaus, Van Allen Eliezer M
Abstract excerpt
Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others. However, larger and uniform genomic analysis may identify additional recurrently mutated genes at lower frequencies. Here we aggregate and uniformly analyze exome sequencing data from 1,013 prostate cancers. We identify and validate a...
Topics
- Androgens
- Carcinogenesis
- Cullin Proteins
- Epigenesis, Genetic
- Exome
- Homeodomain Proteins
- Humans