Article
Analysis of a large prostate cancer family identifies novel and recurrent gene fusion events providing evidence for inherited predisposition.
The Prostate - 1 Apr 2022
Raspin Kelsie, O'Malley Dannielle E, Marthick James R, Donovan Shaun, Malley Roslyn C, Banks Annette, Redwig Frank, Skala Marketa, Dickinson Joanne L, FitzGerald Liesel M
Abstract excerpt
There is strong interest in the characterisation of gene fusions and their use to enhance clinical practices in prostate cancer (PrCa). Significantly, ~50% of prostate tumours harbour a gene fusion. Inherited factors are thought to predispose to these events but, to date, only one study has investigated gene fusions in a familial context. Here, we examined the prevalence and diversity of gene fusions in 14...
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