Article
Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.
Human molecular genetics - 15 Dec 2016
Luedeke Manuel, Rinckleb Antje E, FitzGerald Liesel M, Geybels Milan S, Schleutker Johanna, Eeles Rosalind A, Teixeira Manuel R, Cannon-Albright Lisa, Ostrander Elaine A, Weikert Steffen, Herkommer Kathleen, Wahlfors Tiina, Visakorpi Tapio, Leinonen Katri A, Tammela Teuvo L J, Cooper Colin S, Kote-Jarai Zsofia, Edwards Sandra, Goh Chee L, McCarthy Frank, Parker Chris, Flohr Penny, Paulo Paula, Jerónimo Carmen, Henrique Rui, Krause Hans, Wach Sven, Lieb Verena, Rau Tilman T, Vogel Walther, Kuefer Rainer, Hofer Matthias D, Perner Sven, Rubin Mark A, Agarwal Archana M, Easton Doug F, Al Olama Ali Amin, Benlloch Sara, Hoegel Josef, Stanford Janet L, Maier Christiane
Abstract excerpt
Molecular and epidemiological differences have been described between TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined 27 common PrCa risk variants, previously identified in genome-wide association studies, for subtype specific associations in a total of 1221 TMPRSS2:ERG phenotyped PrCa cases. In meta-analyses of a discovery set...
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