Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etiology of prostate cancer with the TMPRSS2:ERG fusion: A systematic review of risk factors.

International journal of cancer - 15 May 2025

McGrath Colleen B, Shreves Alaina H, Shanahan Megan R, Guard Hannah E, Nhliziyo Manelisi V, Pernar Claire H, Penney Kathryn L, Lotan Tamara L, Fiorentino Michelangelo, Mucci Lorelei A, Stopsack Konrad H

Abstract excerpt

The most common somatic alteration in primary prostate cancer is the TMPRSS2:ERG gene fusion, which may be caused or promoted by distinct etiologic factors. The objective of this systematic review was to assess epidemiologic evidence on etiologic factors for prostate cancer by tumor TMPRSS2:ERG fusion status in human populations. Of 3071 publications identified, 19 cohort or case-control studies from six distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AR gene
Share to TMPRSS2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Oncogene Proteins, Fusion

Share to Prostatic Neoplasms

Share to Risk Factors

Share to Serine Endopeptidases

Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 39663641
DOI: 10.1002/ijc.35279
PMCID: PMC11924303

Genes

ERG
TMPRSS2
AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etiology of prostate cancer with the TMPRSS2:ERG fusion: A systematic review of risk factors.PMID 39663641Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

Transcriptomes of Prostate Cancer with TMPRSS2:ERG and Other ETS FusionsSemantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.Semantic proximity Read ↗

Significance of the TMPRSS2:ERG gene fusion in prostate cancer.Semantic proximity Read ↗

Exploring therapeutic applications of PTEN, TMPRSS2:ERG fusion, and tumour molecular subtypes in prostate cancer managementSemantic proximity Read ↗

TMPRSS2-ERG Gene Fusion and Clinicopathologic Characteristics of Korean Prostate Cancer PatientsSemantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Comprehensive analysis of oncogenic signatures and consequent repurposed drugs in TMPRSS2:ERG fusion‐positive prostate cancerSemantic proximity Read ↗

Fusion in the ETS gene family and prostate cancerSemantic proximity Read ↗

TMPRSS2-ERG Fusion Heterogeneity in Multifocal Prostate Cancer: Clinical and Biologic ImplicationsSemantic proximity Read ↗

Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.