Article

Germline determinants of the prostate tumor genome

2022-11-17

Abstract excerpt

A person’s germline genome strongly influences their risk of developing cancer. Yet the molecular mechanisms linking the host genome to the specific somatic molecular phenotypes of individual cancers are largely unknown. We quantified the relationships between germline polymorphisms and somatic mutational features in prostate cancer. Across 1,991 prostate tumors, we identified 23 co-occurring germline and somatic...

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Literature Corpus work: 2ca971de-80ae-51ef-900b-912844e3203c
DOI: 10.1101/2022.11.16.516773

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