Article

Oligodendroglia vulnerability in the human dorsal striatum in Parkinson’s disease

2025-01-20

Abstract excerpt

Oligodendroglia are the responsible cells for myelination in the central nervous system and their involvement in Parkinson’s disease (PD) is poorly understood. We performed snRNA-seq and image-based spatial transcriptomics of human caudate nucleus and putamen (dorsal striatum) from PD and Control brain donors to elucidate the diversity of oligodendroglia and how they are affected by the disease. We have defined fi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5672d1dc-0157-52e4-b24e-2d7af8189e58
DOI: 10.1101/2025.01.15.633167

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oligodendroglia vulnerability in the human dorsal striatum in Parkinson’s diseaseDOI 10.1101/2025.01.15.633167Read

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson’s Disease and Multiple System AtrophySemantic proximity Read

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disordersSemantic proximity Read

Changes in oligodendroglial subpopulations in Parkinson’s diseaseSemantic proximity Read

Transcriptomic changes in oligodendrocytes and precursor cells predicts clinical outcomes of Parkinson’s diseaseSemantic proximity Read

Molecular Disease Stages of Oligodendrocytic and Neuronal Tau Burden in Progressive Supranuclear PalsySemantic proximity Read

A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disordersSemantic proximity Read

Single-cell transcriptomic atlas of the human substantia nigra in Parkinson’s diseaseSemantic proximity Read

A molecular atlas of cell-type specific signatures in the parkinsonian striatumSemantic proximity Read

Oligodendrocyte subtype diversity underlines clinical progression in Parkinson’s diseaseSemantic proximity Read

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALSSemantic proximity Read

Single-nuclei paired multiomic analysis of young, aged, and Parkinson’s disease human midbrain reveals age- and disease-associated glial changes and their contribution to Parkinson’s diseaseSemantic proximity Read

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s DiseaseSemantic proximity Read