Article

Single cell multiomic analyses reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory response

2024-06-13

Abstract excerpt

<title>Abstract</title> Background <italic>DNMT3A</italic> and <italic>TET2</italic> are epigenetic regulator genes commonly mutated in age-related clonal hematopoiesis (CH). Despite having opposing epigenetic functions, these mutations are associated with increased all-cause mortality and a low risk for progression to hematological neoplasms. While individual impacts on the epigenome have been described usin...

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Literature Corpus work: 294562f8-7590-53b9-850b-b749978bdb00
DOI: 10.21203/rs.3.rs-4481664/v1

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