Article
Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation.
Blood advances - 23 Jul 2024
Heimlich J Brett, Bhat Pawan, Parker Alyssa C, Jenkins Matthew T, Vlasschaert Caitlyn, Ulloa Jessica, Van Amburg Joseph C, Potts Chad R, Olson Sydney, Silver Alexander J, Ahmad Ayesha, Sharber Brian, Brown Donovan, Hu Ningning, van Galen Peter, Savona Michael R, Bick Alexander G, Ferrell P Brent
Abstract excerpt
ABSTRACT: Clonal hematopoiesis (CH) is an age-associated phenomenon that increases the risk of hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk through inflammation in the peripheral blood.1 Here, we profile peripheral blood gene expression in 66 968 single cells from a cohort of 17 patients with CH and 7 controls. Using a novel mitochondrial DNA barcoding approach, we were...
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