Back to search

Article

Single cell multiomic analyses reveal divergent effects of <i>DNMT3A</i> and <i>TET2</i> mutant clonal hematopoiesis in inflammatory response

2022-08-26

Abstract excerpt

<h4>ABSTRACT</h4> DNMT3A and TET2 are epigenetic regulators commonly mutated in age related clonal hematopoiesis (CH). Despite having opposed epigenetic functions, these mutations are associated with increased all-cause mortality and a low risk for progression to hematological neoplasms. While individual impacts on the epigenome have been described using different model systems, the phenotypic complexity in huma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
96c2038f-6bf5-5a3e-86dd-6830b64c26bc
DOI
10.1101/2022.08.25.505316
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single cell multiomic analyses reveal divergent effects of <i>DNMT3A</i> and <i>TET2</i> mutant clonal hematopoiesis in inflammatory responseDOI 10.1101/2022.08.25.505316
Single cell multiomic analyses reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory responseSemantic proximity
Single-cell multiomics reveal divergent effects of DNMT3A- and TET2- mutant clonal hematopoiesis in inflammatory responseSemantic proximity
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesis.Semantic proximity
Multiomic Profiling of Human Clonal Hematopoiesis Reveals Genotype and Cell-Specific Inflammatory Pathway ActivationSemantic proximity
Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation.Semantic proximity
Single-cell multi-omics of human clonal hematopoiesis reveals that <i>DNMT3A</i> R882 mutations perturb early progenitor states through selective hypomethylationSemantic proximity
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.Semantic proximity
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.Semantic proximity
Human TET2-Mutant Clonal Hematopoiesis Expansion Is Driven by Distinct Inflammatory Signaling Responses in Stem Cells Versus Myeloid Progeny.Semantic proximity
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19Semantic proximity
DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cellsSemantic proximity
Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal hematopoiesisSemantic proximity
Select a neighboring publication to make it the new centre.