Article
DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.
Blood - 10 Aug 2017
Buscarlet Manuel, Provost Sylvie, Zada Yassamin Feroz, Barhdadi Amina, Bourgoin Vincent, Lépine Guylaine, Mollica Luigina, Szuber Natasha, Dubé Marie-Pierre, Busque Lambert
Abstract excerpt
Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 related and unrelated hematologically normal individuals (ages 55 to 101 years). We used a sensitive...
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