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Oncogenic and teratogenic effects of <i>Trp53</i> <sup>Y217C</sup> , an inflammation-prone mouse model of the human hotspot mutant <i>TP53</i> <sup>Y220C</sup>

2024-09-29

Abstract excerpt

Missense “hotspot” mutations localized in six p53 codons account for 20% of TP53 mutations in human cancers. Hotspot p53 mutants have lost the tumor suppressive functions of the wildtype protein, but whether and how they may gain additional functions promoting tumorigenesis remain controversial. Here we generated Trp53 Y217C , a mouse model of the human hotspot mutant TP53 Y220C . DNA damage responses were lost...

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Literature Corpus work
29441600-2ece-5fcf-8444-64713cdfe2da
DOI
10.1101/2024.09.26.615223
Open publication

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Oncogenic and teratogenic effects of <i>Trp53</i> <sup>Y217C</sup> , an inflammation-prone mouse model of the human hotspot mutant <i>TP53</i> <sup>Y220C</sup>DOI 10.1101/2024.09.26.615223
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