Article
A transactivation-deficient mouse model provides insights into Trp53 regulation and function.
Nature genetics - 1 Sept 2000
Jimenez G S, Nister M, Stommel J M, Beeche M, Barcarse E A, Zhang X Q, O'Gorman S, Wahl G M
Abstract excerpt
The gene Trp53 is among the most frequently mutated and studied genes in human cancer, but the mechanisms by which it suppresses tumour formation remain unclear. We generated mice with an allele encoding changes at Leu25 and Trp26, known to be essential for transcriptional transactivation and Mdm2 binding, to enable analyses of Trp53 structure and function in vivo. The mutant Trp53 was abundant, its level was not...
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