Article

Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors

2025-03-14

Abstract excerpt

The TP53 tumor suppressor gene is mutated in a large fraction of human tumors. Close to 11% of TP53 mutations are nonsense mutations, causing premature termination of protein synthesis and expression of truncated inactive p53 protein. The most common TP53 nonsense mutation in human cancer is R213X. To study the impact of TP53 nonsense mutations in vivo , we generated mice harboring the Trp53 nonsense mutatio...

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Literature Corpus work: 9fa9bddd-7fdc-53b3-ab45-53053b9b3bba
DOI: 10.1101/2025.03.12.642796

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