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Article

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2005

Krummel Kurt A, Lee Crystal J, Toledo Franck, Wahl Geoffrey M

Abstract excerpt

P53 is an unstable transcription factor that is mutated in a majority of human cancers. With a significant role in initiating cell elimination programs, a network has evolved to fine-tune P53 transcriptional output and prevent errant activation. Modifications of the C terminus have long been viewed as critical binary determinants of P53 stability or activation. However, these conclusions are based on in vitro...

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Identifiers

PMID: 16006521
DOI: 10.1073/pnas.0503068102
PMCID: PMC1177381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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