Article
Isoform-specific Disruption of the <i>TP73</i> Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin
2022-08-07
Abstract excerpt
TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α−η). ΔNp73 is primarily expressed in neuronal cells and necessary for neuronal development. Interestingly, while TAp73α is a tumor suppressor and predominantly expressed in normal cells, TAp73 is found to be frequently altered in human cancers, suggesting a role of TAp73 C-terminal isoforms in tumorigenesis....
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Identifiers and source
- Literature Corpus work
- acd6a0ac-43f5-598b-9bff-00108d2659df
- DOI
- 10.1101/2022.08.07.503085